[26]. In the present analysis, we propose that PML is activating a site for the assembly of transcriptional complexes that contain β-catenin. It has previously been reported that Tcf4 and β-catenin can bind to PML in colorectal cancer cell lines [41], although that report indicated that only PML isoform IV was bound to β-catenin. In the present work, we have not dissected which PML isoform was involved in the observed binding, but this binding was observed both with native PML and with an expression construct corresponding to PML isoform III [25]. This evidence concerns the gene TCF4 and colorectal cancer.