Because bone tumors from Prkar1a+/− mice bone tumors were heterogeneous, including elements of myxomatous, cartilaginous, and bony differentiation with aberrant bone architecture [4], we turned to the well-established MC3T3-E1 cell line to study the crosstalk between PKA and β-catenin in osteoblast cells. Here, PRKAR1A is linked to bone neoplasm.