Therefore, the high frequency of CDX2 staining in colorectal adenocarcinomas, staining in extraintestinal tumors with intestinal-type epithelium, and uncommon staining in tumors from various sites lacking an intestinal phenotype sugg4ests that it is a useful marker for intestinal-type differentiation [14, 33]. Here, CDX2 is linked to colorectal adenocarcinoma.