NFKB1 and bacterial infectious disease: In the case of bacterial infection including TB, several immune response factors, such as nuclear factor kappa beta (NF-κB) and tumor necrosis factor-α (TNF-α) in human monocytes, play important roles in innate immunity and function, leading to migration of NF-κB into the nucleus by immune signal transduction via TLR2 [28, 29].