Increased activity of heme oxygenase-1 (HMOX1), which generates CO and biliverdin (subsequently converted to bilirubin), has been reported to exert anti-atherogenic properties and promote vascular repair [28], and HMOX gene promoter polymorphism has been linked to the susceptibility to CAD in diabetic patients through its influence on serum bilirubin and ferritin levels [29]. Here, HMOX1 is linked to coronary artery disorder.