In a multivariate analysis adjusted for age, BMI, the duration of diabetes, drinking, and smoking status, a history of CVD, HbA1c, SBP, DBP, ALT, TC, TG, HDL-C, eGFR and the use of insulin, ACEi/ARB, or statins (Table 4; model 2), TB levels were inversely associated with a greater risk of a high PWV, both as a continuous variable [a 1-SD difference; odds ratio (OR), 0.70; 95% confidence interval (CI), 0.54–0.90; P = 0.005] and when categorized in tertiles (the highest vs. the lowest tertile; OR, 0.49; 95% CI, 0.28–0.85; P = 0.011) in women. The gene discussed is INS; the disease is diabetes mellitus.