Interleukin 1β (IL-1β) is considered the most important cytokine in the pathogenic process of inflammation in RA; it induces proliferation of rheumatoid arthritis synovial fibroblasts (RASFs), and production of high levels of MMPs and prostaglandin E2 (PGE2) via COX expression by RASFs [3]. Here, IL1B is linked to rheumatoid arthritis.