Here, we report results of a case-control study investigating the association of three important SNPs of P450 (CYP1B1*2 G355T, CYP1B1*3 C4326G, and CYP2E1*5 G-1293C) and two major environmental factors (smoking and drinking) with susceptibility to laryngeal cancer. The gene discussed is CYP2E1; the disease is laryngeal carcinoma.