ADRB2 and asthma: Here we extend our analysis in four important ways, to consider i) 6 additional polymorphisms, namely IL13-c.144 G/A, ADRB2-c.16 A/G, ADAM33-V4 C/G, ADAM33-S1 c.710 G/A, GSDML-236 C/T and STAT6-21 C/T (guided by a literature review summarized in Table 1), ii) the asthma persistence and severity classes according to GINA guidelines, iii) the most common allergens in the island and iv) the FEV1/FVC lung function indexes.