Most notably, glutamate secretion and mGluR1 activation in KSHV latently infected cells occurred through two independent pathways regulated by two individual viral latent proteins, LANA-1 and Kaposin A. Our data highlight how KSHV LANA-1 and Kaposin A proteins contribute to the generation of glutamate, activation of mGluR1, and strongly suggest the possibility of exploiting the glutamatergic system for the therapeutic intervention of KSHV dependent cancers. The gene discussed is GRM1; the disease is cancer.