LPS-pretreated TLR4-positive/myeloid differentiation 88 (MyD88)-positive mantle cell lymphoma(MCL) inhibited the proliferation and cytolytic activity of T cells by secreted IL-10 and VEGF, and triggers a cascade that leads to MCL growth and evasion from immune surveillance [29]. The gene discussed is MYD88; the disease is mantle cell lymphoma.