NFKB1 and diabetic kidney disease: An experimental study (6), (7) suggested that the mechanisms of A. membranaceus action in diabetic nephropathy are a reduction in the mRNA level of nuclear factor kappa B (NFκB), which has been suggested to play a key role in the pathogenesis of diabetic nephropathy, and an increase in inhibitory NFκB protein mRNA expression in the renal cortex.