Across 522 RCC tumors, VHL was mutated in 179 (34.3%) samples and lost at the copy number level in 419 (71.3%) samples, while 39.7% of samples exhibited concurrent mutation and CNL, RBX1, CUL2, CUL5, TCEB2, and TCEB2 did not appear to be significantly altered in RCC at DNA level, with no complex components exceeding a CNL frequency of 4% and no mutation frequency reaching 1%. Here, VHL is linked to renal cell carcinoma.