Some studies demonstrate that extracellular S100A8/A9 complex exhibits growth-inhibitory properties and promotes cytotoxicity and apoptosis in many different human tumor cells, strongly indicating that S100A8/A9 elicit powerful anti-tumor responses, and that the cell death pathway mediated by these proteins might therefore provide targets for developing novel therapeutic tools against cancers. This evidence concerns the gene IGKV1D-22 and neoplasm.