CD8A and infection: Three weeks after the last immunization, the mice were challenged with 1.5 × 106 PFU of HRSV B. Seven days after infection, there was a trend toward lower body weight loss, less pulmonary CD8+T-cell infiltration, and lower levels of HRSV B-specific RNA in the lungs of HBc-SHeB-vaccinated mice as compared to HBc-vaccinated control mice (Supplementary Fig S2E–G).