As shown in Figure 3B, rs2839494 and rs1078272 are located in an ERα-binding segment spanning 803 bp, containing three half-ERE sequences and covering exon 10 of TMPRSS3. In addition, at a region 9.5 kb 5' of this segment, there is a gene, TFF1, which has been shown to be a suppressor of breast cancer in a mouse model [23]. This evidence concerns the gene ESR1 and breast cancer.