Remarkably, giant platelets and thrombocytopenia can also be observed in patients lacking FLNa or with a defect in FLNa content as well as in patients with VWD-type 2B, characterized by an increased affinity of VWF for GPIb-IX-V (see section VWF and pathologies) [49–51]. Here, VWF is linked to Thrombocytopenia.