Interestingly some core genes showed organ-specific patterns, e.g. Ap1, Sp1 and PI3k, but the majority of core genes were involved in all organs, including Trp53, NFκb, Tnfα, Fos, Stat3, Myc, Ifng and Erbb2. If such pathways are of critical importance it is possible that the control of organ specificity of cancer development occurs at a different level with different pathways having different roles in different organs. Here, TNF is linked to cancer.