Moreover, RES and CUR treatment have been shown to be effective in patients with T2DM by improving insulin sensitivity, and decreasing fasting blood glucose, HbA1c, triglyceride levels, and body weight (Brasnyó et al. 2011, Chuengsamarn et al. 2012, Kumar & Joghee 2013, Movahed et al. 2013). Here, INS is linked to type 2 diabetes mellitus.