This assertion comes after a 9-month study, involving a pre-diabetic population, which demonstrated that CUR treatment could not only lower HbA1c and homeostasis model assessment of insulin resistance (HOMA-IR) levels (a measure of insulin sensitivity), but also decelerate the deterioration of pre-diabetes to T2DM (Chuengsamarn et al. 2012). This evidence concerns the gene INS and diabetes mellitus.