BRAF [14,15] and EGFR (epidermal growth factor receptor) [16] genes, which are important co-factors of KRAS gene in the EGFR signaling pathway in the carcinogenesis, invasion and metastasis of colorectal cancers, also have prognostic value for patients with metastasis of adenocarcinoma. The gene discussed is BRAF; the disease is colorectal cancer.