At the same time, western blot analysis showed that the protein expression levels of P-gp and GST-π were also higher than those of negative control cells and mock transfected cells, thus, we suggest that microRNA 490-3P may be involved in the development of drug resistance through regulating MDR1/P-gp and GST-π expression in ovarian cancer cells. This evidence concerns the gene PGP and ovarian carcinoma.