AKT1 and hematologic disorder: Since it has been previously described that in hematological malignancies [22, 23] and solid tumors [24, 25] with constitutive PI3K/Akt activation, the rapamycin derivative inhibitor everolimus (RAD001) increased Akt phosphorylation, we sought to explore if Torin-2 might prevent Akt re-activation after mTORC1 inhibition.