AKT1 and acute lymphoblastic leukemia: In conclusion, our data indicate that the novel mTORC1/mTORC2 kinase inhibitor Torin-2 can suppress the growth of both Ph+ and Ph− B-pre ALL cells and extend the finding that the antiproliferative and proapoptotic effects of PI3K/Akt/mTOR pathway inhibitors are independent from ABL-translocation, as reported in long-term cultures of Ph+ and Ph− B-precursor ALL cells from patients [40].