Finally, taking into account that a limited number of animals studies are available on the anti-cancer effects of polyphenols, we evaluated the in vivo effects of single and combined RES and CUR treatment in hampering the growth of transplanted Neu-overexpressing BALB-neuT salivary gland cancer cells (SALTO) in BALB/c mice. The gene discussed is ERBB2; the disease is salivary gland cancer.