Here we hypothesize that, by regulating more than one signalling mediators as NO and ROS through VEGF, Akt and NOX4, small targeted-molecules like NS1 may alter redox fluxes between the tumor and its micro-environment and possibly leading to “normalization” of tumor blood vessels [38, 53] and reduction of angiogenesis/metastasis. Here, NOX4 is linked to neoplasm.