Those include ESR1, MAPT, GATA3, ZNF703, FOXA1, SOX4 and SOX9. Notably, we found that those lncRNAs were positively associated with the expression of the neighboring genes, suggesting that lncRNAs are cis-acting elements that influence master breast cancer regulators, and thus drive breast carcinogenesis (Table S2). The gene discussed is ESR1; the disease is breast cancer.