Interestingly, upon determination of mRNA and protein levels for NGF, TRKA and VEGF in normal ovary, benign tumors, borderline tumors, well differentiated EOC, moderately differentiated ovarian cancer and poorly differentiated ovarian cancer specimens, we found a sustained increase of NGF, TRKA and VEGF both transcripts as well as proteins in the epithelia of such tissues, evidencing a correlation with EOC progression. This evidence concerns the gene NTRK1 and benign neoplasm.