As organotypic cultures obtained from HPV-positive cells at low passage number (FK16A p19 and FK18B p27) exhibit morphological alterations reminiscent of mild/moderate dysplasia while those obtained from the same cells at high passage number (p > 80) exhibit more severe dysplastic features, we can hypothesise that MCT4, CD147, GLUT1 and CAIX are increased during HPV-associated lesion. Here, CA9 is linked to dysplasia.