In 1990, Gonen et al. [9] have demonstrated that ovulation may be also triggered by GnRH agonist, causing the release of both endogenous LH and FSH, while in 2008, Shapiro et al. [10] have established the concept of ‘Dual trigger’, combining both hCG and GnRH-agonists, aiming to trigger ovulation with the questionable ability to prevent severe ovarian hyperstimulation syndrome [11,12]. The gene discussed is GNRH1; the disease is ovarian hyperstimulation syndrome.