NOX4 and pterygium: Oxidative stress is the major pathogenesis of pterygium [1]–[5], we recently reported that SERPINA3K plays an antioxidant role in the corneal epithelium [13], we then identified if SERPINA3K inhibited PECs through targeting the reactive oxygen species (ROS) system, for example, regulations of the key enzyme of the ROS generation system: NADPH oxidase 4 (NOX4) [16]–[18] and the antioxidants of the ROS system: such as, NAD(P)H dehydrogenase (quinone 1) (NQO1), NF-E2–related factor-2 (NRF2) and superoxide dismutases (SOD2) [19]–[23].