Immunoglobulin E has also been detected in serum over albumin [63], whereas an anti- F. tularensis aptamer cocktail, when tested in a sandwich Aptamer-Linked Immobilized Sorbent Assay (ALISA) and dot blot analysis, exhibited specificity in its ability to bind only to tularemia bacterial antigen from subspecies japonica, holarctica (also known as palaearctica) and tularensis but not to Bartonella henselae, nor to pure chicken albumin or chicken lysozyme, demonstrating the ability of this aptamer cocktail to function as a bacterial detection agent [64]. This evidence concerns the gene LYZ and tularemia.