In non-mucinous, CRC REG4 positivity was a sign of favorable prognosis (p = 0.019, log-rank test); 5-year DSS for patients with positive cytoplasmic REG4 tumor expression was 67.9% (95% CI 60.5–75.3) compared to 57.8% (95% CI 53.5–62.1) for those with no cytoplasmic expression (Figure 3). This evidence concerns the gene REG4 and neoplasm.