HPSE and experimental autoimmune encephalomyelitis: Initial reports suggested that HPSE may promote experimental autoimmune encephalomyelitis (EAE), a murine model of MS, as (i) HPSE was shown to be highly expressed in infiltrating cells during EAE [32], and (ii) that the inhibition of HPSE reduced symptoms of EAE correlating with reduced lesions in the spinal cord [33], [34].