According to their results [46], the IL-4 −590 CC genotype was not associated with a lower risk of HCC when initially adjusted for age, gender, and ethnicity (CC vs. CT/TT, OR: 0.46, 95% CI: 0.16–1.31); however, after further adjustment for HBsAg seropositivity and the number of alcoholic drinks per day (0, <3, or >3), the CC genotype was found to be negatively associated with HCC risk (CC vs. CT/TT, OR: 0.05, 95% CI: 0.01–0.40); in contrast, individuals included in our study were all HBsAg seropositive. The gene discussed is IL4; the disease is hepatocellular carcinoma.