PML and acute promyelocytic leukemia: Arsenic trioxide and tretinoin are indicated for induction of remission and consolidation in patients with acute promyelocytic leukemia (APL), since this disease is characterized by the presence of t (15;17) translocation by FISH or PML/RARA (promyelocytic leukemia/retinoic acid receptor, alpha) expression detected by PCR.(21)