Logistic regression on CVID (versus IgGSD) revealed significant positive association with autoimmune conditions and significant negative associations with IgG1, IgG3, IgA, and CD56+/CD16+ blood lymphocyte levels, but the odds ratio was increased only for autoimmune conditions (6.9 (95% CI 1.3, 35.5)). The gene discussed is IGHG3; the disease is common variable immunodeficiency.