With regard to biomarkers of endothelial cell activation and inflammation, we observed a link between asymmetric dimethylarginine (ADMA) concentration and some features of MeS [14], an association between angiopoietin-2 (Angpt-2) serum levels and the age at the onset of symptoms of AS and disease duration [15], and also a positive correlation between serum levels of osteopontin (OPN) and Angpt-2 [16]. The gene discussed is SPP1; the disease is Meckel syndrome, type 1.