Xu et al. found that miR-145 acts as a tumor suppressor by indirectly downregulating the expression of hypoxia-inducible factor 1 (HIF-1) and vascular endothelial growth factor (VEGF) by targeting p70S6K1, in turn resulting in the inhibition of tumor growth and angiogenesis [81]. The gene discussed is HIF1A; the disease is neoplasm.