NFKB1 and familial pancreatic carcinoma: In the study by Fujiwara et al. [55], NM has been shown to downregulate activities of phosphorylated IkBα, NF-κB, and its target genes, resulting in inhibition of cell adhesion, invasion, and increase of a particular programmed cell death (anoikis) in human pancreatic tumor cell lines. In vivo, intraperitoneal administration of pancreatic cancer cells, pretreated with NM, in nude mice revealed reduced peritoneal metastasis and neovascularization and increased survival compared with controls.