ADM and neoplasm: Indeed, as above described, in the early stages of tumor development several tumor-derived factors (i.e., SCF, adrenomedullin) recruit and activate MCs in tumor microenvironment, leading to the release of tryptase [25, 26], which, in turn, can indirectly stimulate tumor angiogenesis by activating latent MMPs and uPA [23, 24, 75].