NFKB1 and familial pancreatic carcinoma: This leads to downregulation of the cellular inhibitor of apoptosis proteins, c-IAP1 and c-IAP2, resulting in cleavage of poly ADP-ribose polymerase (PARP) and caspase-8-mediated apoptosis in vitro and in vivo: the inhibition of NF-κB activity results in chemosensitization of pancreatic cancer.