Del(5q) cells in MDS or AML patients were demonstrated to be haplodeficient for PP2Acα and CDC25C. Lenalidomide-induced apoptosis in a concentration-dependent fashion in del(5q) AML cells while demonstrating no apoptotic effects in non-del(5q) patient cells or non-del(5q) cell lines (31). This evidence concerns the gene CDC25C and acute myeloid leukemia.