KMT2A and acute myeloid leukemia: In one pediatric study, 35% of patients with TKD-mutant AML also harbored an 11q23/MLL rearrangement (MLL-r) (26% had MLL-AF9) in comparison to 24% of FLT3-wild-type and only 2% of ITD-mutant AML patients with MLL-r (48).