KDR and cancer: These data demonstrate that lenvatinib inhibits the FGFR signaling pathway both in vitro and in vivo and suggest that the antitumor effect of lenvatinib against RO82-W-1 xenografts is attenuated through the inhibition of FGFR signaling in cancer cells, besides antiangiogenic activity through the inhibition of VEGFR2 signaling in endothelial cells.