Wilhelmus et al. showed marked astrocytic PINK1 immunostaining in demyelination lesions of MS and suggested that PINK1 is associating in limiting of cellular injury as a protective factor.39 Another supporting evidence for this relationship is the genetic variability of HLA-DRB5 which has a role in inflammatory aspects of both MS and PD.40 This evidence concerns the gene HLA-DRB5 and Parkinson disease.