TNF and ischemic stroke: However, D-dimer and CRP, exclusively, were independently associated with poor outcome in acute ischemic stroke in a multivariable mode.30 Oto et al. assessed levels of IL1beta, IL-6, IL10, TNF-alpha, catecholamines, epinephrine, and norepinephrine and found that in ischemic stroke plasma cytokines and catecholamines were not predictors of neurological outcome at 1 month.