Furthermore, Xuan et al (20) demonstrated active Hh-Gli signaling in cervical cancer and that expression levels of the Hh-Gli signaling protein were higher in CIN than in normal cervical tissue, suggesting that MTSS1 may be involved in the Hh-Gli signaling pathway through interaction with Gli, allowing the occurrence and development of cervical lesions. This evidence concerns the gene MTSS1 and cervical squamous intraepithelial neoplasia.