To clarify the mechanism of GRP94 involvement in gastric carcinogenesis through ER-α36 signaling, SGC7901 human gastric adenocarcinoma cells were treated with 17β-estradiol (E2) and the expression levels of GRP94 and ER-α36, and the phosphorylation levels of Akt at the Ser473 site (Ser473-Akt) were measured. Here, HSP90B1 is linked to gastric adenocarcinoma.