This duplication region was confirmed by real-time quantitative PCR and real-time reverse transcriptase quantitative PCR.<h4>Conclusions</h4>We suggest three positional candidate genes for intellectual disability and recurrent infection based upon gene function and data from real-time reverse transcriptase quantitative PCR-VAMP8 and RNF181 for intellectual disability and CAPG for recurrent infection. The gene discussed is VAMP8; the disease is Intellectual disability.