Our results are in agreement with previous findings that NaV1.1-encoding gene mutations had no effect on PC firing but could reduce the firing activity in interneurons and cause epileptic seizures (Baulac et al., 1999; Escayg et al., 2000; Claes et al., 2001; Meisler and Kearney, 2005; Catterall et al., 2010). The gene discussed is SCN1A; the disease is Seizure.