Interestingly, these studies revealed that activation of the kinin/B2R pathway may either fuel intracellular parasite outgrowth in splenic macrophages from hamsters, a species that is susceptible to visceral leishmaniasis, or limit parasite survival in thioglycolate-elicited mouse peritoneal macrophages [16]. This evidence concerns the gene BDKRB2 and visceral leishmaniasis.