Studies in mice models of acute Chagas disease [14] and visceral leishmaniasis [16] have recently showed that B2R-deficient mice exhibited impaired development of type-1 effector T cells, the immune dysfunction of the transgenic strain being ascribed to primary deficiency in the maturation of B2R−/− DCs in chagasic mice [14]. The gene discussed is BDKRB2; the disease is visceral leishmaniasis.