Overall, the 12 MYCN-targeting miRNAs in neuroblastoma, show significantly more downregulation during MYCN-driven tumor development, compared to non-targeting miRNAs, as indicated by a shift of the cumulative distribution of the π-values (−log10 p-value *Δ slope) to more negative values (Fig. 4C). Here, MYCN is linked to neuroblastoma.