Buechner and colleagues [3] showed that let-7e-5p, miR-101-3p and miR-202-3p are able to affect MYCN expression in a MYCN amplified neuroblastoma cell line, whereas we found no evidence that they are regulating MYCN in MYCN non-amplified primary neuroblastoma tumors. The gene discussed is MYCN; the disease is neuroblastoma.