Interestingly, of the 5 MYCN-targeting miRNAs with positive correlation to MYCN expression or activity, 3 miRNAs, miR-19a-3p, miR-19b-3p and miR-494-3p, showed significantly increased expression during tumor development (Fig. 4B), further supporting the hypothesis that MYCN induces the expression of these miRNAs. Here, MYCN is linked to neoplasm.