L1CAM and neoplasm: While mice receiving mock- and control siRNA-transfected PC3-Luc cells developed visually evident BLI metastases in as high as 100% (12/12) and 90% (11/12) of the populations, respectively, metastatic tumor growth of L1CAM siRNA-transfected PC3-Luc cells was only detected in fewer than 50% (5/12) of the mice at 7 weeks after the injection (Fig. 2B).