L1CAM and neoplasm: In addition, although tumor-bearing mice revealed no significant differences in the distribution of metastases to specific areas, such as the neck back, chest, hind limb, and craniofacial regions among the three transfected groups (Table 1), the whole-body bioluminescent intensity of mice carrying L1CAM siRNA-transfected PC3-Luc tumors was 1 order of magnitude less than those of mock- and negative control shRNA groups (Fig. 2C).