In our study, L1CAM-mediated metastasis by prostate cancer cells was contradictory to EMT induction, and was even more likely associated with the mesenchymal-to-epithelial transition (MET), based on the expression patterns of E-cadherin and vimentin between L1CAM-deficient and L1CAM-proficient PC3 cells, and L1CAM-null and L1CAM-overexpressing C4-2 cells. This evidence concerns the gene L1CAM and Familial prostate cancer.