This result in conjunction with the data from L1CAM expression in clinical prostate cancer tissue array and patient sera suggests that in primary lesions of prostate cancer, the L1CAM may be characterized as a tumor suppressor due to its strong cell-adhesion function and in a protective role against the carcinoma-related EMT thereby tumor-associated stroma but not localized tumor cells may express and release L1CAM, a chemoattractant and adhesive matrix for cancer metastasis initiation. Here, L1CAM is linked to Familial prostate cancer.