NFKB1 and Familial prostate cancer: In addition, treatment of PC3 cells with IKK inhibitor or NF-kB inhibitor (pyrrolidine dithiocarbamate; PDTC) attenuated their highly invasive phenotype (Fig. S4), providing a mechanistic evidence for the role of IKK/NF-κb signaling pathway in metastatic potential of prostate cancer cells.