The L1CAM was recently identified as a key mediator of tumor progression due to its upregulation in a variety of human tumors, including melanomas [12], renal cancer [13], lung cancer [14], mesotheliomas [15] oral cancer [16], ovarian carcinoma [17], and hepatocellular carcinoma [18] with high correlations with cancer progression. The gene discussed is L1CAM; the disease is neoplasm.