Although the mechanism by which the L1CAM regulates EMT-related gene expression and confers enhanced motility and metastatic abilities to prostate cancer remains to be determined, our study provides a preliminary association between L1CAM expression and activation of the AKT/NF-κB signaling pathway, that may trigger cell growth and expressions of certain pro-metastatic genes, such as MMP-2 and MMP-9 as shown in this study. This evidence concerns the gene MMP2 and prostate cancer.