MAPK8 and cleft palate with or without ankyloglossia, X-linked: This is strongly supported by the findings that inhibition of JNK with SP600125 or ectopic expression of dominant negative c-Jun potently inhibited CPX-induced autophagy, whereas inhibition of ERK1/2 and p38α using U0126 and doramapimod, respectively, failed to prevent CPX-induced autophagy.