Pathways with greater diversity in RD cancers relative to pCR cancers included basal-cell-carcinoma, which includes genes from the Hedgehog, Wnt, TGF and p53 signaling pathways, folate biosynthesis, and dorso-ventral axis formation pathway involving genes from several key signaling pathways including the MAPK and NOTCH (Figure 3D). The gene discussed is TP53; the disease is cancer.